Archive for the ‘cancer’ tag
Calling volunteers! Cancer Research UK has a new project called The Trailblazer Project. The goal is to develop an app that improves how users analyze cancer pathology data. Volunteers to help test the prototype.
The Cancer Research UK’s Citizen Science team is committed to finding innovative ways to accelerate research by crowdsourcing. Already, the team has three web-based projects up and running. Their new project channels the success of their earliest app Cell Slider. Cell Slider asked participants to identify cancer cells from healthy cells. The team found the public was able to identify cancer cells with a promising degree of accuracy. Now they are developing a new analysis mechanic which will allow for even greater levels of accuracy.
Early beta testing by pathologists and volunteers showed promising levels of agreement. The final iteration of the new mechanic will be ready for testing by volunteers in early August. Testing involves looking for cancer cells in tissue slides rendered into images on an online platform. Each image is divided into 12 sections, and testers click on regions they suspect contains cancerous cells. The team needs at least 30 volunteers to help with this final round of testing.
Once finished, the analysis mechanic will be made available either as a web-based app or a mobile game. This is a unique opportunity for volunteers to not only learn about cancer but to be directly involved in project development. Register to volunteer by emailing your full name to email@example.com.
This project is part of our Back to School 2013 round-up of projects. Read more about them!
Breast cancer is the single most common cancer in women worldwide with roughly 1 in 8 women developing the disease each year. Chances are, a friend or family member is coping with this diagnosis right now. Following Angelina Jolie’s announcement earlier this year about her family’s struggle with breast cancer and her treatment choices, advances in biomedical research and personalized medicine increasingly hold the promise of a day when cancer is cured. How do scientists find the clues buried within tumor samples?
Cell Slider, a collaboration between Cancer Research UK and Zooniverse, is the first citizen scientist project whose goal is to speed up cancer research by enlisting citizen scientists to analyze real tumor samples. According to Professor Andrew Handby, a CRUK scientist from the University of Leeds who helped develop Cell Slider, “Computers can only go so far – they can pick up obvious trends but only the human eye can spot subtleties that have, in the past, lead to important serendipitous discoveries… Cell Slider makes our data accessible – it’s not just for scientists and computer geeks – everyone can play their part in curing cancer.”
Ideal for secondary school science classes, Cell Slider is a real-life citizen scientist project that uses the same methods researchers use everyday in the laboratory to identify cancer cells. Students are introduced to some of the common core principles in life sciences, including basic cell types and shapes, while developing analytical and critical thinking skills. You don’t have to be a scientist to participate in this project; simple mouse clicks help researchers around the world find new cancer treatments buried in simple tumor samples.
During a brief tutorial, students are introduced to the three cell types typically seen on the microscope slides (white blood cells, tissue cells, and cancer cells), taught to identify normal and cancer cells based on shape and staining, then asked to analyze real images of breast cancer tumors. A special yellow dye that sticks to oestrogen receptor (ER) helps identify cells with excessive ER and candidates for cancer treatments using hormonal therapies such as tamoxifen. Once the irregularly shaped, yellow-stained, cancer cells are identified you estimate their number and how strongly they are stained through a matching game. Using this data, researchers are beginning to understand the connections between molecules found on cancer cells and the effects of common treatments on the outcome of the disease.
“Eventually, we hope to be able to identify different types of breast, and other, cancers and find out how these different types respond to different treatments,” said Professor Paul Pharoah, a CRUK scientist from Cambridge University who helped develop Cell Slider. “This will enable us to match up women with the right cancer drugs based on their tumor type. We hope that this personalized medicine approach would be a reality in years to come, but this computer program could make it a reality sooner than any of us had imagined possible.”
Since its launch in October 2012, more than 860,000 citizen scientists from around the world have analyzed over 1.7 million images. Could we be just your mouse click away from a cure?
Photo : Cell Slider
Dr Melinda T. Hough is a freelance science advocate and writer. Her previous work has included a Mirzayan Science and Technology Graduate Policy Fellowship at the National Academy of Sciences (2012), co-development of several of the final science policy questions with ScienceDebate.org (2012), consulting on the development of the Seattle Science Festival EXPO day (2012), contributing photographer for JF Derry’s book “Darwin in Scotland” (2010) and outreach projects to numerous to count. Not content to stay stateside, Melinda received a B.S in Microbiology from the University of Washington (2001) before moving to Edinburgh, Scotland where she received a MSc (2002) and PhD (2008) from the University of Edinburgh trying to understand how antibiotics kill bacteria. Naturally curious, it is hard to tear Melinda away from science; but if you can, she might be found exploring, often behind the lens of her Nikon D80, training for two half-marathons, or plotting her next epic adventure.